Sonochemical synthesis of fluorescent 1,4-disubstituted triazoles using l-phenylalanine as an accelerator ligand in aqueous media |
| |
Authors: | Yachana Jain Mitlesh Kumari Ragini Gupta |
| |
Institution: | 1. Department of Chemistry, Malaviya National Institute of Technology Jaipur, Jaipur, 302017, India;2. Materials Research Centre, Malaviya National Institute of Technology Jaipur, Jaipur, 302017, India |
| |
Abstract: | A green sonochemical protocol using l-phenylalanine as a water soluble promotor ligand has been developed for the regioselective synthesis of fluorogenic 1,4-disubstituted triazoles (3a-o) via well-known click reaction at 40?°C. l-Phenylalanine is a biocompatible, economical, commercially available and non-toxic ligand which not only serves to stabilize Cu(I) oxidation state but also prevents its disproportion to enhances and modulate the rate of reaction. The designed catalytic system exhibits broad substrate compatibility and can be recycled up to 5 cycles without appreciable loss in the yield of desired product. Gram scale synthesis was successfully accomplished with 92% yield. |
| |
Keywords: | Huisgen 1 3-dipolar cycloaddition reaction Ultrasonication Aqueous click reaction Corresponding author |
本文献已被 ScienceDirect 等数据库收录! |
|