Capillary electrophoretic enantioseparation of m‐nisoldipine using two different β‐cyclodextrins |
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Authors: | Dezhi Kong Wei Yang Kunfeng Duan Yang Cui Songsong Xing Xiaowei Zhang Xiaona Sheng Lantong Zhang |
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Affiliation: | 1. Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P.R. China. Fax: +86‐311‐86266419;2. Department of Metabolic Regulation, Institute of Aging and Adaptation, Shinshu University Graduate School of Medicine, Nagano, Japan |
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Abstract: | The methods for the enantioseparation of m‐nisoldipine, a new 1,4‐dihydropyridine calcium ion antagonist, were developed. The elaborated methods of m‐nisoldipine enantiomers separation were successfully performed using an anionic CD–sulfobutyl ether‐β‐CD (SBE‐β‐CD) or carboxymethyl‐β‐CD as chiral selector. However, the results indicated that SBE‐β‐CD was a better chiral selector for enantioseparation of the neutral m‐nisoldipine. Furthermore, comparing the two SBE‐β‐CDs, the derivative with a higher degree of substitution (DS) of 7.0 induced better enantioresolution than the one with low DS (4.0). In addition, possible chiral recognition mechanisms of dihydropyridines were discussed. |
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Keywords: | Capillary electrophoresis Enantioseparation m‐Nisoldipine Recognition mechanisms |
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