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Activation of nitriles by silver(I) N-heterocyclic carbenes: An efficient on-water synthesis of primary amides |
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| Authors: | Narasimha Swamy Thirukovela Ramesh Balaboina Shravankumar Kankala Ravindhar Vadde Chandra Sekhar Vasam |
| Affiliation: | 1. Department of Chemistry, Kakatiya University, Warangal, Telangana State, 506009, India;2. Department of Pharmaceutical Chemistry, Telangana University, Nizamabad, Telangana State, 503322, India |
| Abstract: | A first example of silver(I) N-heterocyclic carbene (Ag(I)-NHC) catalyzed on-water synthesis of primary amides by hydration of nitriles under mild reaction conditions is described. This organometallic catalytic system has excellent tolerance for various homo-aromatic, hetero-aromatic and aliphatic nitriles to afford primary amides in good yields in neat water. |
| Keywords: | Nitrile hydration On-water synthesis Primary amides Bi-phasic catalysis |
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