Pochonins K-P: new radicicol analogues from Pochonia chlamydosporia var. chlamydosporia and their WNT-5A expression inhibitory activities

WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for an inhibitor of WNT-5A expression, and have identified an active compound, radicicol (1), and isolated six new radicicol analogues, pochonins K-P (2-7), together with ten known radicicol analogues, including monorden analogue-1 (8), pochonin E (9), and pochonin F (10), from a culture broth of the fungus Pochonia chlamydosporia TF-0480. This report describes the structural elucidation of 2-7, determination of the stereochemistries of 8-10, and their biological activities against WNT-5A.