Synthesis of 4′-aryl-2′,3′-dideoxynucleoside analogues |
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| Authors: | Artur Jõgi Tõnis Pehk Aleksander-Mati Müürisepp |
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| Institution: | a Department of Chemistry, Faculty of Science, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn, Estonia
b National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia |
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| Abstract: | A series of 4′-aryl-2′,3′-dideoxynucleoside analogues were synthesized from optically pure 5-oxo-2-aryl-tetrahydrofuran-2-carboxylic acids up to 62% overall yield. 5-Oxo-2-aryl-tetrahydrofuran-2-carboxylic acids were obtained from 2-hydroxy-3-arylcyclopent-2-en-1-ones by asymmetric oxidation in up to 38-57% yield. |
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