Synthesis of 1-phenyl- and 1-pyridyl-3-pyridoazepines by reductive cyclization of diarylacetonitriles |
| |
| Authors: | M. Carmen de la Fuente |
| |
| Affiliation: | Departamento de Química Orgánica y Unidad Asociada al CSIC, Facultad de Química, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain |
| |
| Abstract: | Several pyrido[2,3-d]azepines and pyrido[3,4-d]azepines, novel aza analogs of the pharmacologically relevant 1-aryl-3-benzazepines, were synthesized by assembling the azepine ring by reductive cyclization of (2-methoxyvinyl)pyridinyl(aryl)acetonitrile derivatives, which were easily derived from contiguously substituted bromo(2-methoxyvinyl)pyridines and the corresponding arylacetonitriles. |
| |
| Keywords: | Pyrido[2,3-d]azepines Pyrido[3,4-d]azepines Aza-1-aryl-3-benzazepines Reductive cyclization Diarylacetonitriles |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
