A new synthesis of benzo[b]thiophenes utilizing an interrupted Pummerer reaction |
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| Authors: | Kazuhiro Kobayashi Mai Horiuchi Shuhei Fukamachi Hisatoshi Konishi |
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| Institution: | Division of Applied Chemistry, Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan |
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| Abstract: | A convenient synthesis of 3-arylbenzob]thiophenes utilizing an interrupted Pummerer reaction of 2-(1-arylvinyl)phenyl ethyl sulfoxides is described. Thus, treatment of these sulfoxides, which were readily prepared from 2-sulfanylphenyl ketones or 2-fluoro-5-methoxybenzaldehyde, with acetic anhydride at 100 °C afforded 3-arylbenzob]thiophenes in reasonable yields. |
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| Keywords: | Benzo[b]thiophenes Interrupted Pummerer reaction Sulfoxides Acetic anhydride Ring closure |
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