The Vilsmeier reagent: a useful and versatile reagent for the synthesis of 2-azetidinones |
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Authors: | Aliasghar Jarrahpour Maaroof Zarei |
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Affiliation: | Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran |
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Abstract: | (Chloromethylene)dimethylammonium chloride (Vilsmeier reagent), prepared easily from N,N-dimethylformamide and oxalyl chloride or thionyl chloride, works as a versatile acid activator reagent for the direct [2+2] ketene-imine cycloaddition of substituted acetic acid and imines in one-pot synthesis under mild conditions. Monocyclic, spirocyclic and 3-electron-withdrawing group β-lactams were synthesized by this method and optimization of conditions were performed. |
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