Synthesis of 6,7-dihydro-5H-dibenzo[c,e]azepines and biaryls by palladium-catalyzed Ullmann reaction |
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| Authors: | Ming Yu Jin-Heng Li |
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| Institution: | a College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325035, China
b Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha 410081, China |
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| Abstract: | A novel palladium-catalyzed Ullmann protocol is described for the synthesis of 6,7-dihydro-5H-dibenzoc,e]azepines and biaryls. In the presence of Pd(OAc)2 and KOAc, intramolecular or intermolecular Ullmann coupling of aryl halides proceeds efficiently under ligand-free and aerobic conditions to afford the corresponding 6,7-dihydro-5H-dibenzoc,e]azepines and biaryls in moderate to excellent yields. |
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| Keywords: | Palladium The Ullmann reaction 6 7-Dihydro-5H-dibenzo[c e]azepine Biaryls |
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