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Practical synthesis of a peptidomimetic thrombin inhibitor |
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| Authors: | Serge Wilmouth Christel Bufferne-Perret Christine Flouzat Grégoire Humblot Christiane Ray Nadine Simbille |
| Institution: | Schering-Plough France, Preclinical Development Center, 20 rue Henri Goudier, B.P. 140, 63203 Riom Cedex, France |
| Abstract: | Compound 1 is a low molecular weight thrombin inhibitor developed for treatment of deep vein thrombosis and cardiovascular diseases. We herein report our efforts to develop a robust, efficient and reproducible process suitable for large-scale synthesis of compound 1. |
| Keywords: | Low molecular weight thrombin inhibitor Peptidomimetic α-Hydroxy amide oxidation Impurity identification Process development and scale-up |
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