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Pd-catalyzed synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles |
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| Authors: | Saeed Balalaie Hassan MotaghediMorteza Bararjanian Daryoush Tahmassebi Hamid Reza Bijanzadeh |
| Affiliation: | a Peptide Chemistry Research Center, K. N. Tossi University of Technology, PO Box 15875-4416, Tehran, Iran b Chemistry Department, Indiana University-Purdue University Fort Wayne, Fort Wayne, IN 46805, USA c Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran |
| Abstract: | An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach, an Ugi-4-component reaction (4-CR) adduct was used as the starting material. A one-pot sequence involving intermolecular carbopalladation C-H activation/C-C bond formation efficiently afforded the oxindole derivatives. |
| Keywords: | 3-(Diarylmethylene)-2-oxindoles 3-(Arylmethylene)-2-oxindoles Modified Heck reaction Palladium catalyst |
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