Dynamic kinetic resolution of allylic alcohols mediated by ruthenium- and lipase-based catalysts |
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| Authors: | Lee D Huh E A Kim M J Jung H M Koh J H Park J |
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| Institution: | Department of Chemistry, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea. |
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| Abstract: | An enzyme-metal combo reaction has been developed for the dynamic kinetic resolution of allylic alcohols in which racemic substrates are transformed by a lipase and a ruthenium complex in the presence of an acyl donor to allylic acetates of high optical purity in over 80% yield. |
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