Synthesis of two conformationally constrained analogues of the minor tobacco alkaloid anabasine |
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| Authors: | Lindström S Ripa L Hallberg A |
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| Institution: | Department of Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden. |
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| Abstract: | The anabasine analogues spiro4-azaindan-1,2'-piperidine] (7) and spiro6-azaindan-1,2'-piperidine] (8) have been prepared. A series of palladium-catalyzed reactions, where an intramolecular cyclization constituted a key reaction, were utilized for the preparation of the two target compounds. |
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