首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Synthesis and Properties of Conformationally Constrained Analogues of Floral‐Type Odorants
Authors:Serge Lamboley  Cdric Morel  Jean‐Yves de&#x;Saint&#x;Laumer  Andr&#x;F Boschung  Nigel&#x;G&#x;J Richards  Bat&#x;M Winter
Institution:Serge Lamboley,Cédric Morel,Jean‐Yves de Saint Laumer,André F. Boschung,Nigel G. J. Richards,Béat M. Winter
Abstract:The twelve bridged analogues 8 – 19 of floral‐type odorants related to cyclamenaldehyde ( 1 ) were synthesized (Schemes 15) to investigate the relationship between the structural and conformational features of these compounds and their odor properties. Comparison of the data from sensory evaluation and molecular modeling suggests that the side chain of both the unconstrained and the constrained active analogues is not extended (anti) but rather folded (gauche) in the ‘bioactive’ conformation. However, it is mainly the nature of the substituents at the α position of the aldehyde function that critically influences the odor quality and strength. These studies provide new information that should aid ongoing efforts to develop models of odorant? receptor interactions.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号