Synthesis,characterization and biological activity of bis(3‐Aryl‐1‐hexahydropyrimidinyl)methanes. Novel heterocyclic polyamine derivatives |
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| Authors: | Juan Bisceglia María B García Rosana Massa María L Magri Mariana Zani Gabriel O Gutkind Liliana R Orelli |
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| Institution: | Juan Á Bisceglia,María B. García,Rosana Massa,María L. Magri,Mariana Zani,Gabriel O. Gutkind,Liliana R. Orelli |
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| Abstract: | A method is described for the synthesis of bis(3‐aryl‐1‐hexahydropyrimidinyl)methanes 1, by condensation of N‐aryl‐1,3‐propanediarnines 2 with formaldehyde. The reaction mechanism involves N‐arylhexahydropyrimidines 3 as intermediates. Such compounds can also be prepared efficiently by a methylene exchange reaction between bis‐hexahydropyrimidines 1 and the corresponding diamines 2. The antimicrobial activity of compounds 1 was evaluated by the disk diffusion method and some of them showed moderate to good growth inhibition activity. |
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