Pakistolides A and B,Novel Enzyme Inhibitory and Antioxidant Dimeric 4‐(Glucosyloxy)Benzoates from Berchemia pakistanica |
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Authors: | Naveen Mukhtar Abdul Malik Naheed Riaz Kiran Iqbal RasoolBakhsh Tareen ShamsunNahar Khan SarfrazAhmad Nawaz Juveria Siddiqui MIqbal Choudhary |
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Institution: | Naveen Mukhtar,Abdul Malik,Naheed Riaz,Kiran Iqbal,Rasool Bakhsh Tareen,Shamsun Nahar Khan,Sarfraz Ahmad Nawaz,Juveria Siddiqui,M. Iqbal Choudhary |
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Abstract: | Pakistolides A and B, novel dimeric β‐(glucosyloxy)benzoates were isolated from Berchemia pakistanica and assigned structures 1 and 2 on the basis of extensive NMR studies. In addition, the known compounds 7,5′‐dimethoxy‐3,5,2′‐trihydroxyflavone (=3,5‐dihydroxy‐2‐(2‐hydroxy‐5‐methoxyphenyl)‐7‐methoxy‐4H‐1‐benzopyran‐4‐one), 4′,5‐dihydroxy‐3,6,7‐trimethoxyflavone (=5‐hydroxy‐2‐(4‐hydroxyphenyl)‐3,6,7‐trimethoxy‐4H‐1‐benzopyran‐4‐one), 5,6‐dihydroxy‐4,7‐dimethoxy‐2‐methylanthracene‐9,10‐dione, and 1,3,4‐trihydroxy‐6,7,8‐trimethoxy‐2‐methylanthracene‐9,10‐dione were reported for the first time from the genus Berchemia. Both 1 and 2 showed significant α‐glucosidase and lipoxygenase inhibitory activities, while 2 also showed antioxidant potential. |
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