Stereospecific Synthesis of Carbanucleotides Designed for Antisense Methodology

A short stereospecific synthesis of the carbocyclic 2′‐deoxynucleoside analogues 36 and 37 (Schemes 2 and 5) and 45 and 46 (Schemes 2 and 6) starting from optically active 8,9,10‐trinorborn‐5‐en‐2‐one ( 1 ) is described. As two functional groups capable to react with each other are present in the same molecule of the synthetic carbanucleosides, the latter can form polymers similar to oligonucleotides.