Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor |
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| Affiliation: | 1. Center for Advanced Research in Photonics, Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China;2. Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China;1. Optoelectronics Lab, School of Electrical Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul 136-713, Republic of Korea;2. Center for Biomicrosystems, Korea Institute of Science and Technology, Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Republic of Korea;3. Center for Bionics, Biomedical Research Institute, Korea Institute of Science and Technology, Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Republic of Korea;1. Electrical and Electronics Engineering Department, Bilkent University, Bilkent 06800, Ankara, Turkey;2. Faculty of Economic and Administrative Sciences, Bahcesehir University, Besiktas 34353, Istanbul, Turkey;1. Department of Electronics, Carleton University, Ottawa, ON, Canada;2. Center for Biomedical Engineering, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Cambridge, MA 02139, USA;3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA;4. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA;5. WPI-Advanced Institute for Materials Research, Tohoku University, Sendai, Japan;6. Department of Physics, King Abdulaziz University, Jeddah, Saudi Arabia |
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| Abstract: | A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry–Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach–Zehnder configuration, results obtained from salt–water mixtures, antibody–antigen, and protein–DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR. |
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