Diarylthiazole and diarylimidazole selective COX-1 inhibitor analysis through pharmacophore modeling,virtual screening,and DFT-based approaches |
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| Authors: | Crisan Luminita Borota Ana Bora Alina Pacureanu Liliana |
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| Affiliation: | 1.“Coriolan Dragulescu” Institute of Chemistry, Romanian Academy, 24 Mihai Viteazul Ave., 300223, Timisoara, Romania
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| Abstract: | Structural Chemistry - The current work is focused on in silico modeling of COX-1 inhibitors with enhanced safety gastric profile. A 5-point pharmacophore model, atom-based 3D quantitative... |
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