Dibutyltin dimethoxide and BINAP · silver(I) complex-catalyzed asymmetric aldol reaction of alkenyl trichloroacetates with aldehydes |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Chiba University, Inage, Chiba 263-8522, Japan;2. Graduate School of Science and Technology, Chiba University, Inage, Chiba 263-8522, Japan |
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| Abstract: | A catalytic asymmetric aldol reaction of alkenyl trichloroacetates with aldehydes was achieved using dibutyltin dimethoxide and BINAP · silver(I) complex as catalysts in a mixed solvent consisting of THF and MeOH. Various optically active β-hydroxy ketones were diastereoselectively obtained not only from aromatic and α,β-unsaturated aldehydes but also from an aliphatic aldehyde with good enantioselectivity up to 92% ee. |
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