Synthesis,crystal structure,and coordination properties of a helical peptide having β-(3-pyridyl)-l-alanine and l-glutamic acid residues |
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Institution: | 1. Department of Chemistry, Gunma University, Kiryu, Gunma 376-8515, Japan;2. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan |
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Abstract: | A novel helical peptide containing β-(3-pyirdyl)-l-alanine (Pal) and l-glutamic acid (Glu) residues has been designed and successfully prepared as a model ligand of metalloenzyme active sites. The helical peptide, Boc-Leu-Aib-Glu-Leu-Leu-Pal-Aib-Leu-OEt (1) (Boc = tert-butoxycarbonyl, Aib = 2-aminoisobutylic acid) yields fine crystals as an acetnitrile solvate. The metal ion binding affinities of 1 were tested for CoCl2 using UV/vis, CD, Raman, and 1H NMR spectroscopies. The non-linear fitting calculations have revealed the 1:1 complex for CoCl2 with the binding constant 3.6 (±0.7) × 102 M−1. |
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