Nickel(0)-catalyzed disilylative and silastannylative cyclizations of 1,3-diene and tethered aldehyde |
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Institution: | 1. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan;2. Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan |
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Abstract: | Nickel(0)-catalyzed bismetallative cyclization of 1,3-diene and a tethered aldehyde in the presence of PhF2SiSiMe3 or Me3SiSnBu3 gave the corresponding cyclized product having an allylsilyl or an allylstannyl unit in the side chain in good yields. The cyclized product obtained from the reaction in the presence of Me3SiSnBu3 had reactivity as an allylstannane derivative, and the coupling reaction with benzaldehyde proceeded in a diastereoselective manner. When the silastannylative cyclization was carried out in the presence of a chiral monodentate phosphine ligand, the cyclized product was produced as an optically active form with modest enantiomeric excess. |
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