Additive hazards regression with random effects for clustered failure times |
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Authors: | Deng Pan Yan Yan Liu Yuan Shan Wu |
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Institution: | 1. Department of Statistics, Chinese University of Hong Kong, Hong Kong, P. R. China;
2. Department of Statistics, Chinese University of Hong Kong, Hong Kong, P. R. China;
3. School of Mathematics and Statistics, Wuhan University, Wuhan 430072, P. R. China |
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Abstract: | Additive hazards model with random effects is proposed for modelling the correlated failure time data when focus is on comparing the failure times within clusters and on estimating the correlation between failure times from the same cluster, as well as the marginal regression parameters. Our model features that, when marginalized over the random effect variable, it still enjoys the structure of the additive hazards model. We develop the estimating equations for inferring the regression parameters. The proposed estimators are shown to be consistent and asymptotically normal under appropriate regularity conditions. Furthermore, the estimator of the baseline hazards function is proposed and its asymptotic properties are also established. We propose a class of diagnostic methods to assess the overall fitting adequacy of the additive hazards model with random effects. We conduct simulation studies to evaluate the finite sample behaviors of the proposed estimators in various scenarios. Analysis of the Diabetic Retinopathy Study is provided as an illustration for the proposed method. |
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Keywords: | Additive hazards regression clustered failure times counting process empirical process frailty model checking random effects |
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