Extrahelical damaged base recognition by DNA glycosylase enzymes |
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| Authors: | Stivers James T |
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| Institution: | Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe St., WBS 314, Baltimore, MD 21205, USA. jstivers@jhmi.edu |
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| Abstract: | The efficient enzymatic detection of damaged bases concealed in the DNA double helix is an essential step during DNA repair in all cells. Emergent structural and mechanistic approaches have provided glimpses into this enigmatic molecular recognition event in several systems. A ubiquitous feature of these essential reactions is the binding of the damaged base in an extrahelical binding mode. The reaction pathway by which this remarkable extrahelical state is achieved is of great interest and even more debate. |
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| Keywords: | base flipping DNA base dynamics DNA damage DNA glycosylase |
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