| Inhibition of Metalloproteinase Activity by Chinese Formulations Used to Treat Inflammatory Diseases |
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| 作者姓名： | JIN Feng-hai WANG Hui-ling ZHAO Shu-hua YANG Jin-gang FANG Xue-xun |
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| 作者单位： | JIN Feng-hai 1，2，WANG Hui-ling 1，3，ZHAO Shu-hua 4，YANG Jin-gang 1 and FANG Xue-xun 1**1. Key Laboratory of Molecular Enzymology and Engineering，the Ministry of Education，Jilin University，Changchun 130021，P. R. China; 2. School of Pharmacy，Jilin University，Changchun 130021，P. R. China; 3. College of Life Science，Jilin University，Changchun 130021，P. R. China; 4. The China-Japan Union Hospital，Jilin University，Changchun 130021，P. R. China |
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| 基金项目： | Supported by the National Natural Science Foundation of China（ No. 30371656） and Jilin Distinguished Young Scholars Program Grant Award（No. 6-21-10）. |
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| 摘 要： | Introduction Matrixmetalloproteinases(MMPs)areaclassof zinc requiringextracellularendopeptidasesthatcanto getherdegradeallcomponentsoftheextracellularma trixandbasementmembranes1—3].Theyplayimpor tantrolesinconnectivetissueremodeling,occurringin normalb…
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| 关 键 词： | 矩阵金属蛋白酶 抑制剂 中药 草药 疾病处理 分子机理 |
| 文章编号： | 1005-9040（2006）-02-245-03 |
| 收稿时间： | 2005-12-31 |
Inhibition of Metalloproteinase Activity by Chinese Formulations Used to Treat Inflammatory Diseases |
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| JIN Feng-hai WANG Hui-ling ZHAO Shu-hua YANG Jin-gang FANG Xue-xun.Inhibition of Metalloproteinase Activity by Chinese Formulations Used to Treat Inflammatory Diseases[J].Chemical Research in Chinese University,2006,22(2):245-247. |
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| Authors: | Feng-hai JIN Hui-ling WANG Shu-hua ZHAO Jin-gang YANG Xue-xun FANG |
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| Institution: | aKey Laboratory of Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130021, P. R. China;bSchool of Pharmacy, Jilin University, Changchun 130021, P. R. China;cCollege of Life Science, Jilin University, Changchun 130021, P. R. China;dThe China-Japan Union Hospital, Jilin University, Changchun 130021, P. R. China |
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| Abstract: | Matrix metalloproteinases(MMPs) are known to be involved in a number of pathological processes including cancer, atherosclerosis, arthritis and neurodegenerative disease among others. The drive to develop MMP inhibitors as therapeutics has been put forward for years by pharmaceutical companies as well as academicians. In an attempt to screen for MMP inhibitors from Traditional Chinese Medicines(TCMs), a number of Chinese formulations used to treat inflammatory diseases such as nephritis and hepatitis have been studied. Strong inhibitory effects of three Chinese formulations toward the activity of MMP-16 have been discovered. These results suggest that these anti-inflammatory medicines contain some unknown MMP inhibitory compound(s) and provide reasonable molecular mechanisms for their therapeutic effects. |
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| Keywords: | Matrix metalloproteinase(MMP) Matrix metalloproteinase inhibitor(MMPI) Traditional Chinese Medicine(TCM) Herbal formulation |
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