Inhibition of Metalloproteinase Activity by Chinese Formulations Used to Treat Inflammatory Diseases |
| |
| Authors: | Feng-hai JIN Hui-ling WANG Shu-hua ZHAO Jin-gang YANG Xue-xun FANG |
| |
| Affiliation: | aKey Laboratory of Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130021, P. R. China;bSchool of Pharmacy, Jilin University, Changchun 130021, P. R. China;cCollege of Life Science, Jilin University, Changchun 130021, P. R. China;dThe China-Japan Union Hospital, Jilin University, Changchun 130021, P. R. China |
| |
| Abstract: | Matrix metalloproteinases(MMPs) are known to be involved in a number of pathological processes including cancer, atherosclerosis, arthritis and neurodegenerative disease among others. The drive to develop MMP inhibitors as therapeutics has been put forward for years by pharmaceutical companies as well as academicians. In an attempt to screen for MMP inhibitors from Traditional Chinese Medicines(TCMs), a number of Chinese formulations used to treat inflammatory diseases such as nephritis and hepatitis have been studied. Strong inhibitory effects of three Chinese formulations toward the activity of MMP-16 have been discovered. These results suggest that these anti-inflammatory medicines contain some unknown MMP inhibitory compound(s) and provide reasonable molecular mechanisms for their therapeutic effects. |
| |
| Keywords: | Matrix metalloproteinase(MMP) Matrix metalloproteinase inhibitor(MMPI) Traditional Chinese Medicine(TCM) Herbal formulation |
| 本文献已被 CNKI 维普 万方数据 ScienceDirect 等数据库收录！ |
|
