A cellular scale numerical study of the effect of mechanical properties of erythrocytes on the near-wall motion of platelets |
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Authors: | Jing Xu Xiao-Long Wang Yun-Qiao Liu Xiao-Bo Gong |
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Institution: | 1. MOE Key Laboratory of Hydrodynamics, Department of Engineering Mechanics, Shanghai Jiao Tong University, 200240, Shanghai, China 2. SJTU-CU ICRC, Shanghai Jiao Tong University, 200240, Shanghai, China
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Abstract: | The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that with the increase of hematocrit, the near-wall approaching of platelets is enhanced, with which platelets exhibit larger deformation and orientation angle of its near-wall tank-treading motion, and the lateral force pushing platelets to the wall is increased with larger fluctuation amplitude. Meanwhile the near-wall approaching is reduced by increasing the stiffness of erythrocytes. |
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Keywords: | Hemodynamics Fluid-membrane interaction Immersed boundary method Near-wall motion of platelet |
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