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| 单微吸管测量细胞切向粘附力方法的研究 | |
| 引用本文： | 张西正,匡震邦.单微吸管测量细胞切向粘附力方法的研究[J].实验力学,2000,15(1):9-14. |
| 作者姓名： | 张西正 匡震邦 |
| 作者单位： | 1. 军事医学科学院,卫生装备研究所,天津,300161 2. 上海交通大学,工程力学系,上海,200030 3. 教育部生物力学及生物流变学开放研究实验室,重庆大学生物工程学院,重庆400044 |
| 基金项目： | 国家自然科学基金资助项目(39500037)，教育部生物力学及生物流变学开放研究实验室资助项目 |
| 摘 要： | 本文对单微吸管测量细胞切向粘附力的方法进行简要的力学分析，结果表明该方法不失为一种简单易行的切向粘附力测量方法，有助于研究个体细胞与不同基底材料之间的粘附性能，以及不同药物、粘附分子对细胞切向粘附力的影响，扩大了微管吸吮技术的应用范围，并对单微吸管细胞切向粘附力测量方法的测量左范围进行了讨论。通过对人成骨细胞切向粘附力的测量，结果表明该方法可满足细胞生物力学实验的要求。 |
| 关 键 词： | 单微吸管 细胞切向粘附力 人成骨细胞 |
| 文章编号： | 1001-4888(2000)01-0009-06 |
Single Micropipette Aspiration Technique for Measuring the Shearing Adhesion Force of Cells |
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| ZHANG Xi-zhengKUANG Zhen-bangCAI Shao xi,XU Shi-rong,WU Ze-zhi,HUANG Qi-ping.Single Micropipette Aspiration Technique for Measuring the Shearing Adhesion Force of Cells[J].Journal of Experimental Mechanics,2000,15(1):9-14. | |
| Authors: | ZHANG Xi-zhengKUANG Zhen-bangCAI Shao xi XU Shi-rong WU Ze-zhi HUANG Qi-ping |
| Institution: | ZHANG Xi-zheng ;(Insdtute of Medical Equipment, Academy of Military Medical Sciences, Tanjin 300181);KUANG Zhen-bang ;(Engineeanng Mechaoical Departmem, Shanghai jiaotong University, Shanghai 200030);CAI Shao xi ,XU Shi-rong ,WU Ze-zhi ,HUANG Qi-ping ;(The State Educational Ministry Open Laboratory of Biomechanies & Biorhelogy, Bioengineering institute Chongqing University, Chongqing 400044) |
| Abstract: | The single micropipette aspiration technique used for measuring the cellular shearing adhesion force in biomechanics experiments is analyzed by mechanical consideration.The analysis showed that this technique is reasonable and feasible, and it would be helpful for studying the adhesive property between individual cell and different substrate materials, or studying the influence of different medicines or adhesive molecules on the shearing adhesion force of cell.The error range of the technique was discussed. An application example for measuring the shearing adhesion force of human osteoblst cell was given. |
| Keywords: | single micropipette aspiration technique shearing adhesion force of cell humanosteoblasts |
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