Aggregation and interaction of cationic nanoparticles on bacterial surfaces |
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| Authors: | Hayden Steven C Zhao Gengxiang Saha Krishnendu Phillips Ronnie L Li Xiaoning Miranda Oscar R Rotello Vincent M El-Sayed Mostafa A Schmidt-Krey Ingeborg Bunz Uwe H F |
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| Institution: | School of Chemistry and Biochemistry, Georgia Institute of Technology, 910 Atlantic Drive, Atlanta, Georgia 30332, USA. |
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| Abstract: | Cationic monolayer-protected gold nanoparticles (AuNPs) with sizes of 6 or 2 nm interact with the cell membranes of Escherichia coli (Gram-) and Bacillus subtilis (Gram+), resulting in the formation of strikingly distinct AuNP surface aggregation patterns or lysis depending upon the size of the AuNPs. The aggregation phenomena were investigated by transmission electron microscopy and UV-vis spectroscopy. Upon proteolytic treatment of the bacteria, the distinct aggregation patterns disappeared. |
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