Scalable total synthesis of (-)-berkelic acid by using a protecting-group-free strategy |
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| Authors: | Fañanás Francisco J Mendoza Abraham Arto Tamara Temelli Baris Rodríguez Félix |
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| Institution: | Instituto Universitario de Química Organometálica "Enrique Moles", Unidad Asociada al C.S.I.C., Universidad de Oviedo, Spain. fjfv@uniovi.es |
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| Abstract: | Supply chain: the polycyclic core of (-)-berkelic acid (1) was constructed in just one step from very simple starting materials. The total synthesis of 1 involves a seven-step linear sequence. Protection/deprotection steps were avoided and all but the last step were performed on a gram scale. This synthesis could solve the supply problem associated with the exhaustion of the natural source. |
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| Keywords: | antitumor agents multicomponent reactions natural products spiro compounds total synthesis |
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