Biology evolves to fight chemistry |
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| Authors: | Kazlauskas Romas |
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| Institution: | University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108, USA. rjk@umn.edu |
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| Abstract: | A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose. |
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