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An efficient and green preparation of 5-aminophosphonate substituted pyrimidine nucleosides under solvent-free conditions |
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| Authors: | Xin Ying Zhang Ying Ying Qu Xue Sen Fan |
| Affiliation: | School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, China |
| Abstract: | An environmentally benign and highly efficient one-pot preparation of α-aminophosphonates under solvent-free conditions was developed. By employing this method, 5-aminophosphonate substituted pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2'-deoxyuridine, aniline and dimethyl phosphite. |
| Keywords: | Aminophosphonate 5-Substituted pyrimidine nucleoside Solvent-free reaction Green synthesis |
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