Synthesis of Structurally Related Purines: Benzimidazo[1,2-a]pyridines, Benzimidazo-[1,2-c]pyrimidines, and Pyrazolo-[1,5-a]pyrimidines |
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| Authors: | Galal H. Elgemeie Nadia H. Metwally |
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| Affiliation: | (1) Department of Chemistry, Faculty of Science, Helwan University, Helwan, Cairo, Egypt, EG;(2) Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt, EG |
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| Abstract: | Summary. Reactions of sodium salts of 3-hydroxymethylene-2-alkanones with 2-cyanomethylbenzimidazole afforded benzimidazo[1,2-a]pyridines. Analogues reactions with 2-aminobenzimidazole and 5-aminopyrazoles afforded benzimidazo[1,2-c]pyrimidines and pyrazolo[1,5-a]pyrimidines. Received December 12, 1999. Accepted (revised) February 12, 2000 |
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| Keywords: | . 3-Hydroxymethylene-2-alkanone salts Benzimidazole derivatives 5-Aminopyrazoles Benzimidazo pyridines Pyrazolo pyrimidines. |
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