Cell proliferation in normal and malignant transformed cells: thermodynamic model of signal transduction |
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Authors: | Kuznetsov D V Blokhin A V |
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Institution: | Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin Street 4, Moscow 117977, Russia. |
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Abstract: | We present a new thermodynamic model for the mechanism of activation and regulation of cell proliferation in the G1 stage. In this model, the interactions between growth factors and transmembrane proteins play a crucial role in cell growth control for a normal tissue-culture system. We calculate a phase diagram of normal and malignant transformed states of a cell signal transduction system. We propose thermodynamic reasons why cancer cells can continually grow without activation by the growth factors. |
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