| 胶束电动色谱法分离与测定己烯雌酚片剂中的有效成分 |
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| 引用本文： | 贾丽,邵海丽,高文华. 胶束电动色谱法分离与测定己烯雌酚片剂中的有效成分[J]. 分析试验室, 2004, 23(2): 21-23 |
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| 作者姓名： | 贾丽 邵海丽 高文华 |
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| 作者单位： | 汕头大学理学院化学系分析测试中心,汕头,515063;汕头大学理学院化学系分析测试中心,汕头,515063;汕头大学理学院化学系分析测试中心,汕头,515063 |
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| 摘 要： | 建立了一种用来分离测定己烯雌酚的胶束电动色谱法,。通过对十二烷基硫酸钠、胆酸钠、脱氧胆酸钠3种表面活性剂进行比较,选定以60mmol/LSDS 10mmol/L硼砂的水溶液作为背景电解质溶液,研究了不同pH对分离己烯雌酚的影响。该方法被应用于测定己烯雌酚片剂中有效成分的含量。
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| 关 键 词： | 己烯雌酚 胶束电动色谱 分离 测定 |
| 文章编号： | 1000-0720(2004)02-0021-03 |
Separation and determination of active ingredient in diethylstilbestrol tablet by micellar electrokinetic chromatography |
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| JIA Li,SHAO Hai-li and GAO Wen-hua. Separation and determination of active ingredient in diethylstilbestrol tablet by micellar electrokinetic chromatography[J]. Chinese Journal of Analysis Laboratory, 2004, 23(2): 21-23 |
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| Authors: | JIA Li SHAO Hai-li GAO Wen-hua |
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| Affiliation: | JIA Li~*,SHAO Hai-li and GAO Wen-hua |
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| Abstract: | A new micellar electrokinetic chromatography method for the separation and determination of diethylstilbestrol was proposed. The effects of sodium dodecyl sulfate (SDS), sodium cholate (SA)and sodium deoxycholate (DSA) on the separation of diethylstilbestrol were compared. 60 mmol/L SDS-10 mmol/L sodium borate was selected as the background buffer. The influence of the pH of the background electrolyte solution on the separation of diethylstilbestrol was also studied. The method was applied to determine the active ingredient in diethylstilbestrol tablet with satisfactory results. |
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| Keywords: | Diethylstilbestrol Micellar electrokinetic chromatography Separation Determination |
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