The Novel Function of Unsymmetrical Chiral CCN Pincer Nickel Complexes as Chemotherapeutic Agents Targeting Prostate Cancer Cells |
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| Authors: | Jing-Jing Qu Lin-Lin Shi Yan-Bing Wang Jing Yan Tian Shao Xin-Qi Hao Jia-Xiang Wang Hong-Yu Zhang Jun-Fang Gong Bing Song |
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| Affiliation: | College of Chemistry, School of Life Sciences, School of Basic Medical Science, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 100 of Science Road, Zhengzhou 450001, China; (J.-J.Q.); (Y.-B.W.); (J.Y.); (T.S.); (X.-Q.H.); (J.-X.W.) |
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| Abstract: | We report that the pincer nickel complexes display prostate cancer antitumor properties through inhibition of cell proliferation. Notably, they display better antitumor properties than cisplatin. Mechanistic studies reveal that these pincer nickel complexes trigger cell apoptosis, most likely due to cell cycle arrest. Interestingly, these complexes also inhibit androgen receptor (AR) and prostate-specific antigen (PSA) signaling, which are critical for prostate cancer survival and progression. Our study reveals a novel function of pincer nickel complexes as potential therapeutic drugs in prostate cancer. |
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| Keywords: | pincer complex nickel prostate cancer androgen receptor PSA |
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