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Applications of single-drop microextraction in analytical chemistry: A review
Institution:1. Applied Chemistry Department, S. V. National Institute of Technology, Surat, 395007, Gujarat, India;2. Department of Environmental Engineering, Kwangwoon University, Seoul, 139-701, Republic of Korea;3. Department of Chemistry, Research Institute of Chem-Bio Diagnostic Technology, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea;4. Analytical Chemistry Division, Bhabha Atomic Research Center, Trombay, Mumbai, 400085, India;5. Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, 70, Lien-Hai Road, Kaohsiung, 80424, Taiwan;6. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan;7. Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan;8. International PhD Program for Science, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan;1. Laboratorio de Materiales para Análisis Químicos (MAT4LL), Departamento de Química, Unidad Departamental de Química Analítica, Universidad de La Laguna (ULL), Tenerife, 38206, Spain;2. Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna (ULL), Tenerife, 38206, Spain;3. CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal
Abstract:Single-drop microextraction (SDME) has been recognized as one of the simple miniaturized sample preparation tools for the isolation and preconcentration of several analytes from a complex sample matrix. In this review, we explored the applications of SDME coupled with various analytical techniques (spectroscopy, chromatography, and mass spectrometry) for the analysis of organic molecules, inorganic ions, and biomolecules from various sample matrices including food, environmental, clinical, pharmaceutical, and industrial samples. Also, it summarizes the use of nanoparticles in SDME combined with various analytical tools for the rapid analysis of several trace-level target analytes. An overview of ionic liquids, deep eutectic solvents, and SUPRAS, which improved the selectivity and sensitivity of various analytical techniques toward several analytes, as promising extracting solvent systems in SDME is also included. Finally, discussed the impressive analytical features and future perspectives of SDME in this review article.
Keywords:Single-drop microextraction  Nanoparticles  Ionic liquids  Deep eutectic solvents  Analytical instruments  Biomolecules  Organic molecules  Inorganic species
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