Phenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell model |
| |
Authors: | Reuben Klein David Brown Ann M Turnley |
| |
Affiliation: | (1) Centre for Neuroscience, The University of Melbourne, 3010 Parkville, Victoria, Australia;(2) Novogen Ltd, 140 Wicks Road, North Ryde, NSW, Australia |
| |
Abstract: | Background Many commonly used chemotherapeutic agents, such as Cisplatin, are restricted in their potential anti-neoplastic effectiveness by their side effects, with one of the most problematic being induction of peripheral neuropathy. Although a number of different neurotrophic, neuroprotective or anti-oxidant treatments have been tried in order to prevent or treat the neuropathies, to date they have met with limited success. Phenoxodiol is a new chemotherapeutic agent that has anti-proliferative and apoptotic effects on a range of cancer cells. PC12 cells are a commonly used neuronal cell model for examination of neurite outgrowth. In this study we examined whether phenoxodiol could protect against Cisplatin induced neurite inhibition in PC12 cells as an indication of the potential to protect against neuropathy. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|