| Abstract: | Cefoxitin (Hcefoxi) interacts with transition metal ions to give [M(cefoxi)Cl] complexes [M=Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)] which were characterized by physicochemical and spectroscopic methods. A tetrahedral geometry is suggested for their structure, where the cefoxitin behaves as a monoanionic tridentate ligand. The complexes have been screened for antibacterial activity against several bacteria, and the results show that they are less active than the parent cefoxitin. |
