Calibration of activity readings from radiopharmaceuticals with impurities |
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Authors: | Kwo-Ping Chang Ching-Kuei Chen and Lie-Hang Shen |
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Institution: | (1) Department of Radiological Technology, Institute of Radiological Science, Tzi-Chi College of Technology, 880, Sec. 2, Chien-Kuo Road, Hualien, 970, Taiwan, Republic of China;(2) Division of Isotope, Institute of Nuclear Energy Research, Lung-Tan, Taiwan, Republic of China |
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Abstract: | Accurately determining the amount of a radionuclide actually administered to a patient is an important aspect of quality control
in nuclear medicine. In this study, in order to accurately assess the “apparent” radioactivities of radionuclides with impurities
by a dose calibrator, two methods, (1) curve fitting, and (2) relative sensitivities calculation, have been employed to determine
the parameter, M (relative response). From the comparisons between the measurement and re-calculated radioactivity using the M values, each method was found to have its own advantage and disadvantage, depending upon the fraction ratio of the impurity
as well as the energy level of the impurity’s photons. This study might be helpful for improving the assessment of radiopharmaceuticals’
“true” activity and its “apparent” activity measured by a dose calibrator. |
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