Microgels formed by electrostatic and hydrophobic interaction of naphthaleneacetic acid with β-cyclodextrin-grafted polyethyleneimine |
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Authors: | Mi Sun Lee Jin-Chul Kim |
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Institution: | (1) Division of Biotechnology and Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University, 192–1, Hyoja 2 dong, Chunchon, Kangwon-do, 200–701, South Korea; |
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Abstract: | Microgels were prepared by physically cross-linking β-cyclodextrin-grafted polyethyleneimine (βCD-PEI) using a hydrophobic
acidic compound, naphthaleneacetic acid (NAA). Under a strong acidic condition (e.g., pH 3.0), fibrous microgels were observed
on a scanning electron microscope (SEM) possibly due to the intermolecular electrostatic interaction of NAA with PEI. In the
range of pH 4.0 to pH 8.0, globular microgels were found possibly because an intramolecular electrostatic interaction prevails
over an intermolecular interaction. At pH 9.0 and pH 10.0, neither fibrous nor globular microgels were observed due to lack
of the electrostatic interaction and the hydrophobic interaction of NAA with βCD-PEI. The release of fluorescein isothiocyanate-dextran
(FITC-dextran; M.W., 10,000) from the microgels increased with increasing pH. At pHs higher than pH 3.0, not only the diffusion
of the solute, but also the dissolution of the microgels could contribute to the release. |
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Keywords: | |
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