Surface engineering of carbon dots for highly sensitive α-glucosidase assay and inhibition evaluation |
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作者姓名: | Meijuan Liang Gege Song Yeqing Wan Yingying Chen Fuan Wang Xiaoqing Liu |
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作者单位: | 2. Oil Crops Research Institute, Chinese Academy of Agricultural Sciences |
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基金项目: | supported by National Natural Science Foundation of China (Nos. 32202171, 22274121 and 22274123); |
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摘 要: | Monitoring α-glucosidase(α-Glu) activity is of great significance for the early diagnosis of type Ⅱ diabetes. Here the blue fluorescent carbon dots(CDs) were integrated with two different recognizing molecules, β-cyclodextrin and phenylboronic acid, for assembling a multifunctional CDs(mCDs) nanoplatform for sensitively analyzing α-Glu and its inhibitors. The hydrolyzed product of 4-nitrophenyl-α-D-glucopyranoside(α-Glu substrate), p-nitrophenol, could efficiently quench the fluorescence of mCDs...
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