Total synthesis of herbimycin A |
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Authors: | Canova Sophie Bellosta Véronique Bigot Antony Mailliet Patrick Mignani Serge Cossy Janine |
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Affiliation: | Laboratoire de Chimie Organique, associé au CNRS, ESPI, 10 rue Vauquelin, 75231 Paris Cedex 05, France. |
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Abstract: | [structure: see text] Hsp90 has recently emerged as a promising biological target for treatment of cancer. Herbimycin A and other members of the benzoquinoid ansamycin class of natural products are known to inhibit Hsp90 activity. The total synthesis of herbimycin A was achieved from the commercially available Roche ester 1 by using allylmetals to control the stereogenic centers at C6, C7, C10, C11, and C12 and a ring-closing metathesis to control the (Z)-double bond of the (E,Z)-dienic moiety. |
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