G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection |
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| Authors: | Schouten James A Ladame Sylvain Mason Stephen J Cooper Matthew A Balasubramanian Shankar |
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| Institution: | University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. |
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| Abstract: | G-quadruplex DNA-specific ligands were generated using a combinatorial selection of tetrapeptides which were then conjugated to a hemicyanine scaffold. The heterocycle enhanced peptide binding affinity by approximately 1000-fold to give ligands with near micromolar affinity and >40-fold discrimination for quadruplex DNA over duplex. |
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