Investigation of a flexible enantiospecific approach to aziridines |
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| Authors: | Jamookeeah Clare E Beadle Christopher D Jackson Richard F W Harrity Joseph P A |
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| Affiliation: | Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, United Kingdom. |
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| Abstract: | A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a convenient one-pot procedure is outlined that allows the trityl group to be exchanged for a range of common N-protecting groups. |
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