Oligoresorcinols fold into double helices in water |
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Authors: | Goto Hidetoshi Katagiri Hiroshi Furusho Yoshio Yashima Eiji |
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Institution: | Yashima Super-structured Helix Project, ERATO, Japan Science and Technology Agency (JST), 101 Creation Core Nagoya, 2266-22 Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan. |
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Abstract: | We report the first double helices with a controlled helicity in water based on oligoresorcinols as a new, simplest water-soluble structural motif. The molecular strands of the oligoresorcinols self-assemble into double helices with the aid of aromatic interactions in water as characterized by 1H NMR and absorption spectroscopies together with the X-ray crystallographic study of the pentamer. The double helix formation is sensitive to the chain length, solvent composition, and temperature. Moreover, a bias in the screw sense of the double helices was achieved by covalently attaching chiral substituents to both ends of the molecular strands. |
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