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RP-HPLC determination of lipophilicity in series of quinoline derivatives |
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| Authors: | Robert Musiol Josef Jampilek Barbara Podeszwa Jacek Finster Dominik Tabak Jiri Dohnal Jaroslaw Polanski |
| Institution: | (1) Institute of Chemistry, University of Silesia, 40007 Katowice, Poland;(2) Zentiva a.s., 10237 Prague 10, Czech Republic;(3) Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 61242 Brno, Czech Republic |
| Abstract: | In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active
compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation
and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure
of the studied compounds.
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| Keywords: | Lipophilicity RP-HPLC Microwave synthesis Quinoline derivatives |
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