Copper-catalyzed asymmetric reduction of 3,3-diarylacrylonitriles |
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| Authors: | Lee Daehyung Yang Youngmin Yun Jaesook |
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| Affiliation: | Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon 440-746, Korea. |
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| Abstract: | CuH-catalyzed enantioselective conjugate reduction of 3,3-diaryl-substituted acrylonitriles is described. A range of 3-aryl-3-pyridylacrylonitriles were reduced with high levels of enantioselectivity under optimal conditions employing a copper/Josiphos complex in the presence of polymethylhydrosiloxane (PMHS). |
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