Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C |
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| Authors: | Bates Robert H Shotwell J Brad Roush William R |
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| Institution: | Department of Chemistry, Scripps Florida, Jupiter, Florida 33458, USA. |
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| Abstract: | Stereoselective syntheses of the C(1)-C(9) fragments 18 and 28 of amphidinolide C have been developed. The first-generation sequence involves a diastereoselective chelate-controlled 3 + 2]-annulation reaction of 6 and 7, while the second-generation synthesis involves an intramolecular hetero-Michael cyclization of 8. |
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