| Ligudentatin A的全合成 |
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| 引用本文： | 张晨曦,毕福强,李裕林.Ligudentatin A的全合成[J].高等学校化学学报,2008,29(11):2191-2193. |
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| 作者姓名： | 张晨曦 毕福强 李裕林 |
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| 作者单位： | 兰州大学有机化学研究所,功能有机分子化学国家重点实验室,兰州,730000 |
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| 基金项目： | 国家自然科学基金
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| 摘 要： | 以(+)-紫苏醇2为起始原料, 经氧化、Witting、Diels-Alder和烯酮的芳构化等反应, 最终以17.7%的总收率完成了去甲基倍半萜Ligudentatin A(1)的全合成, 其中Diels-Alder和烯酮的芳构化反应为关键步骤.
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| 关 键 词： | Ligudentatin A 全合成 Diels-Alder反应 芳构化反应 |
| 收稿时间： | 2008-04-01 |
Total Synthesis of Ligudentatin A |
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| ZHANG Chen-Xi,BI Fu-Qiang,LI Yu-Lin.Total Synthesis of Ligudentatin A[J].Chemical Research In Chinese Universities,2008,29(11):2191-2193. |
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| Authors: | ZHANG Chen-Xi BI Fu-Qiang LI Yu-Lin |
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| Institution: | State Key Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
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| Abstract: | Ligudentatin A(1),a new phenolic norsesquiterpenes,was first synthesized starting from( )-perillalalcohol 2 through six steps,successively,with an overall yield of 17.7%.The key steps were the Diels-Alder reaction and aromatization of enone to phenol.The advantages of this approach are reasonable yields and the ease with which the reaction can be carried out with readily available materials and reagents under mild conditions. |
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| Keywords: | Ligudentatin A |
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