Ferrocene Derivatives of Valine and Leucine

Methyl and ethyl esters of valine and leucine were reacted with ferrocenecarbaldehyde to obtain azomethines (C₅H₅)Fe(C₅H₄CH=NCHRCOOR′) whose reactions with sodium borohydride provide ferrocenylmethyl derivatives (C₅H₅)Fe(C₅H₄CH₂NHCHR⋅COOR′) [R=(CH₃)₂CH, (CH₃)₂CHCH₂; R′ = CH₃, C₂H₅]. The latter compounds react with sodium hydroxide to give, after treatment of the reaction mixtures with acetic acid, N-substituted amino acids (C₅H₅)Fe(C₅H₄CH₂NHCHRCOOH).__________Translated from Zhurnal Obshchei Khimii, Vol. 75, No. 6, 2005, pp. 1046–1048.Original Russian Text Copyright © 2005 by Popova, Yurashevich, Cherevin, Gulevich, Reshetova, Knizhnikov.